Ryosuke miura biography definition

The present series of books, published as the 95th anniversary project of Shueisha, is a quite ambitious one which aims at delineating the whole history of Asia from the dawn of civilizations to modern times through the biographies of diverse figures who have lived in Asia. It is an unprecedented attempt involving more than one hundred and seventy authors of diverse disciplines, not limited to history, in depicting as many as ten thousand historical figures. The fact that such a project could be launched and completed demonstrates the deep layers of Asian studies accumulated in Japan through the ages.
 
Volumes are divided period-wise, with some overlaps, and each chapter basically forms a cluster consisting of a main figure and the others related with her/him. The relations among those figures are defined widely and include not only the actual social connections but also relations formed by contemporaneity, by influences of ideas and activities, and even by perceptions of later generations. A reader may pick up and read a volume covering a person or a period which interests her/him. Going through the entire volume beyond a single chapter or a cluster, s/he will realize that an unimaginably wid

•

A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs

Introduction

While apoptosis has been considered to be a typical form of programmed or regulated cell death, recent studies have revealed novel types of regulated or programmed cell death, including necroptosis, pyroptosis, and ferroptosis^1,2. Necroptosis is morphologically similar to necrosis and can be induced by virus infection, or death ligands including tumor necrosis factor (TNF), Fas ligand, and TRAIL when caspase activation is blocked^3,4,5. Upon stimulation with these death ligands, sequential phosphorylation and activation of receptor-interacting protein kinase (RIPK)1 and RIPK3 are induced. Activated RIPK3 phosphorylates mixed lineage kinase domain-like (MLKL), resulting in a conformational change of MLKL. Phosphorylated MLKL forms oligomers and translocates to biological membranes, resulting in the execution of necroptosis through pore formation and membrane rupture^6,7.

Danger-associated molecular pattern (DAMP)s are host-derived molecules released from dead cells through ruptured nuclear and cytoplasmic membranes. DAMPs include nuclear proteins such as High-Mobility Group Box (HMGB)1 and histones but also heat shock proteins, IL-1 family members, and ATP^8,9. A previou

•

Black Butler

Japanese manga series highest its franchise

First tankōbon volume revive, featuring Sebastian Michaelis
Genre
Written by	Yana Toboso
Published by	Square Enix
English publisher
Imprint	G Fantasy Comics
Magazine	Monthly GFantasy
English magazine
Demographic	Shōnen
Original run	September 16, 2006 – present
Volumes	34 (List of volumes)
Further information Directed by Produced by Hiroo Maruyama Hiroyuki Shimizu Shunsuke Saito Mikihiro Iwata Written by Mari Okada Music by Taku Iwasaki Studio A-1 Pictures Licensed by Original network MBS English network Original run Oct 3, 2008 – Sep 17, 2010 Episodes 36 + 7 OVA (List of episodes) Directed by Noriyuki Abe Produced by Yasutaka Kimura Kozue Kaneniwa Ryū Hashimoto Shinobu Satō Ayako Yokoyama Katsunori Kubo Hirotsugu Ogisu Written by Hiroyuki Yoshino Music by Yasunori Mitsuda Studio A-1 Pictures Licensed by Original network MBS English network Original run July 10, 2014 – September 12, 2014 Episodes 10 (List of episodes) Directed by Noriyuki Abe Produced by Yasutaka Kimura Kozue Ka